The life sciences sector has experienced a challenging 2025, marked by federal policy shifts under the Trump administration, including proposed cuts to National Institutes of Health funding, withdrawal of government backing for mRNA vaccine initiatives, new tariffs, and drug pricing reforms.

Philadelphia’s biotech ecosystem has felt the impact. Nearly 1,000 local life sciences jobs have been lost as companies scaled back research programs to preserve capital — a continuation of contraction that began in 2023. Venture capital activity has slowed as well, with only a few funding rounds surpassing $25 million and no IPOs so far this year.

Despite the slowdown, there’s cautious optimism. At the Philadelphia Business Journal’s recent State of the Biotech Industry forum, industry experts noted that while many organizations are proceeding conservatively, there are still meaningful opportunities for innovation and adaptation across the sector.

*Article courtesy of Philadelphia Business Journal

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